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transfemscience.org/articles/sublingual-e2-transfem/index.html
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<?xml version="1.0" encoding="utf-8"?><feed xmlns="http://www.w3.org/2005/Atom" ><generator uri="https://jekyllrb.com/" version="3.10.0">Jekyll</generator><link href="https://transfemscience.org/feed-posts.xml" rel="self" type="application/atom+xml" /><link href="https://transfemscience.org/" rel="alternate" type="text/html" /><updated>2025-09-15T15:56:48-07:00</updated><id>https://transfemscience.org/feed-posts.xml</id><title type="html">Transfeminine Science</title><subtitle>Transfeminine Science is a site for information on hormone therapy for transfeminine people.</subtitle><author><name>Transfeminine Science</name></author></feed>
<?xml version="1.0" encoding="utf-8"?><feed xmlns="http://www.w3.org/2005/Atom" ><generator uri="https://jekyllrb.com/" version="3.10.0">Jekyll</generator><link href="https://transfemscience.org/feed-posts.xml" rel="self" type="application/atom+xml" /><link href="https://transfemscience.org/" rel="alternate" type="text/html" /><updated>2025-10-14T13:17:19-07:00</updated><id>https://transfemscience.org/feed-posts.xml</id><title type="html">Transfeminine Science</title><subtitle>Transfeminine Science is a site for information on hormone therapy for transfeminine people.</subtitle><author><name>Transfeminine Science</name></author></feed>

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transfemscience.org/feed.xml
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<?xml version="1.0" encoding="utf-8"?><feed xmlns="http://www.w3.org/2005/Atom" ><generator uri="https://jekyllrb.com/" version="3.10.0">Jekyll</generator><link href="https://transfemscience.org/feed.xml" rel="self" type="application/atom+xml" /><link href="https://transfemscience.org/" rel="alternate" type="text/html" /><updated>2025-09-15T15:56:48-07:00</updated><id>https://transfemscience.org/feed.xml</id><title type="html">Transfeminine Science | Articles</title><subtitle>Transfeminine Science is a site for information on hormone therapy for transfeminine people.</subtitle><author><name>Transfeminine Science</name></author><entry><title type="html">A Review of Pharmaceutical Interventions for Scalp Hair Loss and Implications for Transfeminine People</title><link href="https://transfemscience.org/articles/hair-loss/" rel="alternate" type="text/html" title="A Review of Pharmaceutical Interventions for Scalp Hair Loss and Implications for Transfeminine People" /><published>2025-09-08T18:00:00-07:00</published><updated>2025-09-09T00:00:00-07:00</updated><id>https://transfemscience.org/articles/hair-loss</id><content type="html" xml:base="https://transfemscience.org/articles/hair-loss/"><![CDATA[<h1 id="a-review-of-pharmaceutical-interventions-for-scalp-hair-loss-and-implications-for-transfeminine-people">A Review of Pharmaceutical Interventions for Scalp Hair Loss and Implications for Transfeminine People</h1>
<?xml version="1.0" encoding="utf-8"?><feed xmlns="http://www.w3.org/2005/Atom" ><generator uri="https://jekyllrb.com/" version="3.10.0">Jekyll</generator><link href="https://transfemscience.org/feed.xml" rel="self" type="application/atom+xml" /><link href="https://transfemscience.org/" rel="alternate" type="text/html" /><updated>2025-10-14T13:17:19-07:00</updated><id>https://transfemscience.org/feed.xml</id><title type="html">Transfeminine Science | Articles</title><subtitle>Transfeminine Science is a site for information on hormone therapy for transfeminine people.</subtitle><author><name>Transfeminine Science</name></author><entry><title type="html">A Review of Pharmaceutical Interventions for Scalp Hair Loss and Implications for Transfeminine People</title><link href="https://transfemscience.org/articles/hair-loss/" rel="alternate" type="text/html" title="A Review of Pharmaceutical Interventions for Scalp Hair Loss and Implications for Transfeminine People" /><published>2025-09-08T18:00:00-07:00</published><updated>2025-09-09T00:00:00-07:00</updated><id>https://transfemscience.org/articles/hair-loss</id><content type="html" xml:base="https://transfemscience.org/articles/hair-loss/"><![CDATA[<h1 id="a-review-of-pharmaceutical-interventions-for-scalp-hair-loss-and-implications-for-transfeminine-people">A Review of Pharmaceutical Interventions for Scalp Hair Loss and Implications for Transfeminine People</h1>
<!-- Supports up to four authors per article currently (author, author2, author3, author4) -->
@ -2771,17 +2771,17 @@ Figure 5. Meta-analysis of estradiol concentration-time data from cisgender wome
<li>Yáñez, J. A., Remsberg, C. M., Sayre, C. L., Forrest, M. L., &amp; Davies, N. M. (2011). Flip-flop pharmacokinetics–delivering a reversal of disposition: challenges and opportunities during drug development. <em>Therapeutic Delivery</em>, <em>2</em>(5), 643–672. [DOI:<a href="https://doi.org/10.4155/tde.11.19">10.4155/tde.11.19</a>]</li>
<li>Zhang, Y., Huo, M., Zhou, J., &amp; Xie, S. (2010). PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel. <em>Computer Methods and Programs in Biomedicine</em>, <em>99</em>(3), 306–314. [DOI:<a href="https://doi.org/10.1016/j.cmpb.2010.01.007">10.1016/j.cmpb.2010.01.007</a>]</li>
<li>Zhou, X. F., Shao, Q. X., Han, X. J., Weng, L. J., &amp; Sang, G. W. (1998). Pharmacokinetics of medroxyprogesterone acetate after single and multiple injection of Cyclofem<sup>®</sup> in Chinese women. <em>Contraception</em>, <em>57</em>(6), 405–411. [DOI:<a href="https://doi.org/10.1016/S0010-7824(98)00048-1">10.1016/S0010-7824(98)00048-1</a>]</li>
</ul>]]></content><author><name>{&quot;first_name&quot;=&gt;&quot;Aly&quot;, &quot;last_name&quot;=&gt;&quot;W.&quot;, &quot;author-link&quot;=&gt;&quot;/about/#aly&quot;, &quot;articles-link&quot;=&gt;&quot;/articles-by-author/aly/&quot;}</name></author><category term="github" /><category term="workspace" /><summary type="html"><![CDATA[An Informal Meta-Analysis of Estradiol Curves with Injectable Estradiol Preparations By Aly | First published July 16, 2021 | Last modified May 8, 2025]]></summary></entry><entry><title type="html">An Exploration of Sublingual Estradiol as an Alternative to Oral Estradiol in Transfeminine People</title><link href="https://transfemscience.org/articles/sublingual-e2-transfem/" rel="alternate" type="text/html" title="An Exploration of Sublingual Estradiol as an Alternative to Oral Estradiol in Transfeminine People" /><published>2021-06-11T20:26:25-07:00</published><updated>2025-08-07T00:00:00-07:00</updated><id>https://transfemscience.org/articles/sublingual-e2-transfem</id><content type="html" xml:base="https://transfemscience.org/articles/sublingual-e2-transfem/"><![CDATA[<h1 id="an-exploration-of-sublingual-estradiol-as-an-alternative-to-oral-estradiol-in-transfeminine-people">An Exploration of Sublingual Estradiol as an Alternative to Oral Estradiol in Transfeminine People</h1>
</ul>]]></content><author><name>{&quot;first_name&quot;=&gt;&quot;Aly&quot;, &quot;last_name&quot;=&gt;&quot;W.&quot;, &quot;author-link&quot;=&gt;&quot;/about/#aly&quot;, &quot;articles-link&quot;=&gt;&quot;/articles-by-author/aly/&quot;}</name></author><category term="github" /><category term="workspace" /><summary type="html"><![CDATA[An Informal Meta-Analysis of Estradiol Curves with Injectable Estradiol Preparations By Aly | First published July 16, 2021 | Last modified May 8, 2025]]></summary></entry><entry><title type="html">An Exploration of Sublingual Estradiol as an Alternative to Oral Estradiol in Transfeminine People</title><link href="https://transfemscience.org/articles/sublingual-e2-transfem/" rel="alternate" type="text/html" title="An Exploration of Sublingual Estradiol as an Alternative to Oral Estradiol in Transfeminine People" /><published>2021-06-11T20:26:25-07:00</published><updated>2025-08-14T00:00:00-07:00</updated><id>https://transfemscience.org/articles/sublingual-e2-transfem</id><content type="html" xml:base="https://transfemscience.org/articles/sublingual-e2-transfem/"><![CDATA[<h1 id="an-exploration-of-sublingual-estradiol-as-an-alternative-to-oral-estradiol-in-transfeminine-people">An Exploration of Sublingual Estradiol as an Alternative to Oral Estradiol in Transfeminine People</h1>
<!-- Supports up to four authors per article currently (author, author2, author3, author4) -->
<p>By
<!-- First author --><a href="/about/#sam">Sam</a><!-- Second author --><!-- Third author --><!-- Fourth author --> | First published June 11, 2021
| Last modified August 7, 2025</p>
| Last modified August 14, 2025</p>
<h2 id="abstract--tldr">Abstract / TL;DR</h2>
<p>Sublingually-administered estradiol is an alternative route of administration to oral estradiol that has been used by a limited number of gender clinics around the world. We do not currently know if sublingual estradiol results in better, worse, or similar feminisation as other routes of administration because there is a paucity of clinical data in this area. There may be practical shortcomings associated with the sublingual route, however clinical experience suggest it to be effective and affordable when dosed correctly. Although much more research is clearly needed to properly characterise this route of administration, sublingual estradiol might have some advantageous properties and may be a useful alternative to oral estradiol for some transfeminine people.</p>
<p>Sublingually-administered estradiol is an alternative route of administration to oral estradiol that has been used by a limited number of gender-affirming care providers internationally. We do not currently know if sublingual estradiol results in better, worse, or similar feminisation as other routes of administration because there is a paucity of clinical data in this area. There may be practical shortcomings associated with the sublingual route, however clinical experience suggest it to be effective and affordable when dosed correctly. Although much more research is clearly needed to properly characterise this route of administration, sublingual estradiol might have some advantageous properties and may be a useful alternative to oral estradiol for some transfeminine people.</p>
<h2 id="introduction">Introduction</h2>
@ -3023,7 +3023,7 @@ Figure 5. Meta-analysis of estradiol concentration-time data from cisgender wome
<li>Yaish, I., Gindis, G., Greenman, Y., Moshe, Y., Arbiv, M., Buch, A., Sofer, Y., Shefer, G., &amp; Tordjman, K. (2023). Sublingual Estradiol Offers No Apparent Advantage Over Combined Oral Estradiol and Cyproterone Acetate for Gender-Affirming Hormone Therapy of Treatment-Naive Trans Women: Results of a Prospective Pilot Study. <em>Transgender Health</em>, <em>8</em>(6), 485–493. [DOI:<a href="https://doi.org/10.1089/trgh.2023.0022">10.1089/trgh.2023.0022</a>]</li>
<li>Yaish, I., Greenman, Y., Sofer, Y., &amp; Tordjman, K. M. (2024). Response to Ruggles and Cheung, Re:” Sublingual Estradiol Offers No Apparent Advantage Over Combined Oral Estradiol and Cyproterone Acetate for Gender-Affirming Hormone Therapy of Treatment-Naive Trans Women: Results of a Prospective Pilot Study”. <em>Transgender Health</em>, <em>9</em>(5), 460-461. [DOI:<a href="https://doi.org/10.1089/trgh.2024.0105">10.1089/trgh.2024.0105</a>]</li>
<li>Yaish, I., Buch, A., Gindis, G., Sofer, Y., Arbiv, M., Moshe, Y., … &amp; Tordjman, K. (2025). Early body composition changes in trans women on low-dose estradiol: comparing oral vs sublingual administration using dual energy absorptiometry and bioelectrical impedance analysis. <em>The Journal of Sexual Medicine</em>, <em>22</em>(4), 625-635. [DOI:<a href="https://doi.org/10.1093/jsxmed/qdaf005">10.1093/jsxmed/qdaf005</a>]</li>
</ul>]]></content><author><name>{&quot;first_name&quot;=&gt;&quot;Sam&quot;, &quot;last_name&quot;=&gt;&quot;S.&quot;, &quot;author-link&quot;=&gt;&quot;/about/#sam&quot;, &quot;articles-link&quot;=&gt;&quot;/articles-by-author/sam/&quot;}</name></author><category term="github" /><category term="workspace" /><summary type="html"><![CDATA[An Exploration of Sublingual Estradiol as an Alternative to Oral Estradiol in Transfeminine People By Sam | First published June 11, 2021 | Last modified August 7, 2025]]></summary></entry><entry><title type="html">Clinical Guidelines with Information on Transfeminine Hormone Therapy</title><link href="https://transfemscience.org/articles/transfem-hormone-guidelines/" rel="alternate" type="text/html" title="Clinical Guidelines with Information on Transfeminine Hormone Therapy" /><published>2020-11-20T10:00:00-08:00</published><updated>2024-11-17T00:00:00-08:00</updated><id>https://transfemscience.org/articles/transfem-hormone-guidelines</id><content type="html" xml:base="https://transfemscience.org/articles/transfem-hormone-guidelines/"><![CDATA[<h1 id="clinical-guidelines-with-information-on-transfeminine-hormone-therapy">Clinical Guidelines with Information on Transfeminine Hormone Therapy</h1>
</ul>]]></content><author><name>{&quot;first_name&quot;=&gt;&quot;Sam&quot;, &quot;last_name&quot;=&gt;&quot;S.&quot;, &quot;author-link&quot;=&gt;&quot;/about/#sam&quot;, &quot;articles-link&quot;=&gt;&quot;/articles-by-author/sam/&quot;}</name></author><category term="github" /><category term="workspace" /><summary type="html"><![CDATA[An Exploration of Sublingual Estradiol as an Alternative to Oral Estradiol in Transfeminine People By Sam | First published June 11, 2021 | Last modified August 14, 2025]]></summary></entry><entry><title type="html">Clinical Guidelines with Information on Transfeminine Hormone Therapy</title><link href="https://transfemscience.org/articles/transfem-hormone-guidelines/" rel="alternate" type="text/html" title="Clinical Guidelines with Information on Transfeminine Hormone Therapy" /><published>2020-11-20T10:00:00-08:00</published><updated>2024-11-17T00:00:00-08:00</updated><id>https://transfemscience.org/articles/transfem-hormone-guidelines</id><content type="html" xml:base="https://transfemscience.org/articles/transfem-hormone-guidelines/"><![CDATA[<h1 id="clinical-guidelines-with-information-on-transfeminine-hormone-therapy">Clinical Guidelines with Information on Transfeminine Hormone Therapy</h1>
<!-- Supports up to four authors per article currently (author, author2, author3, author4) -->